Lung Epithelial Cells: Eosinophil Eosinophil Migration Across Monolayers of Triple Role of Platelet-Activating Factor in

Epithelial Cell Activator Chemoattractant and Priming Agent and Lung Epithelial Cells: Eosinophil Eosinophil Migration Across Monolayers of Triple Role of Platelet-Activating Factor in

Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration

Leukocyte extravasation is mediated by multiple interactions of adhesive surface structures with ligands on endothelial cells and matrix components. The functional role of beta 1 (CD29) integrins (or very late antigen [VLA] proteins) in eosinophil migration across polycarbonate filters was examined under several in vitro conditions. Eosinophil migration induced by the chemoattractant C5a or pla...

Interleukin-8 plays a significant role in IgE-mediated lung inflammation.

Interleukin (IL)-8 is a potentially important cytokine in allergic respiratory responses since it is released by many resident lung cells, and it is a potent granulocyte chemoattractant. Therefore, we induced an immunoglobulin (Ig)E-mediated response in human lung samples and studied whether IL-8 was produced in sufficient quantities to promote human neutrophil and eosinophil migration across n...

Distinct Calcium Signaling Mechanisms in Across Lung Epithelial Monolayers by Regulation of Human Eosinophil Migration

A CD18/ICAM-1-dependent pathway mediates eosinophil adhesion to human bronchial epithelial cells.

Eosinophil adhesion to airway epithelium is believed to facilitate eosinophil accumulation and retention in asthmatic airways. Monoclonal antibodies (mAb) against intercellular adhesion molecule-1 (ICAM-1) and its CD18 leukocyte integrin ligands have been shown to inhibit airway eosinophilia in animal models of asthma, although the role of this pathway in eosinophil-epithelial adhesion is not f...